BackgroundCoronary vasospasm is a known side effect of 5-FU (fluorouracil) therapy.Beyond switching to non-5FU-based chemotherapy, there are no established treatments for 5-FU associated coronary vasospam.Our objective was to assess the safety and efficacy of re-challenge with 5-FU after pre-treatment with calcium channel blockers (CCBs) and long-a
Deep learning for sea cucumber detection using stochastic gradient descent algorithm
A large number of natural products secluded from sea atmosphere has been identified for the pharmacodynamic probable in varied illness handlings, such as, tumor or inflammatory states.Sea cucumber culturing and fishing is mainly reliant on physical works.For quick and precise programmed recognition, deep residual networks with various forms used to
Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells
Human mast cells (MCs) contain rose jelly beans TG-rich cytoplasmic lipid droplets (LDs) with high arachidonic acid (AA) content.Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for eicosanoid generation by activated human primary MCs in culture.Silencing of ATGL in MC
Caveolins: Targeting Pro-survival Signaling in the Heart and Brain
The present review pale pink sns discusses intracellular signaling moieties specific to membrane lipid rafts (MLRs) and the scaffolding proteins caveolin and introduces current data promoting their potential role in the treatment of pathologies of the heart and brain.MLRs are discreet microdomains of the plasma membrane enriched in gylcosphingolipi